Featured Publications

Li X, Turaga D, Tsai CR, Li RG, Spinner JA, Hickey EJ, Adachi I, and Martin JF. (2024). The Macrophage Landscape Across the Lifespan of a Human Cardiac Allograft. Circulation 149, 1650-1666. PMCID: PMC11105989 (available on 2025-05-21); doi: 10.1161/CIRCULATIONAHA.123.065294.

Li RG, Li X, Canozo FJG, Morikawa Y, Meng F, Kim JH, Xie B, Liu S, Samee MAH, and Martin JF. (2024). YAP Induces a Neonatal Like Pro-Renewal Niche in the Adult Heart. Nat Cardiovascular Research 3, 283-300. PMCID: PMC10954255; DOI: 10.1038/s44161-024-00428-w.

Liu S, Li K, Wagner Florencio L, Tang L, Heallen TR, Leach JP, Wang Y, Grisanti F, Willerson JT, Perin EC, Zhang S, and Martin JF. (2021). Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Science Translational Medicine 13, eabd6892. PMCID: PMC9476348; DOI: 10.1126/scitranslmed.abd6892.

Xiao Y, Hill MC, Li L, Deshmukh V, Martin TJ, Wang J, and Martin JF. (2019). Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis. Genes and Development 33, 1491-1505. PMCID: PMC6824468; DOI: 10.1101/gad.329763.119.

Monroe TO, Leach JP, Hill MC, Morikawa Y, Wehrens XHT, Rodney GG, and Martin JF. (2019). Yap partially reprograms chromatin accessibility to directly induce cardiogenesis in vivo. Developmental Cell 48, 765-779. PMCID: PMC6435425; DOI: 10.1016/j.devcel.2019.01.017.

Leach JP, Heallen TR, Zhang M, Hill MC, Rahmani M, Willerson JT, and Martin JF. (2017). Hippo Pathway Deletion Reverses Systolic Heart Failure Post Infarction. Nature 550, 260-264. PMCID: PMC5729743; DOI: 10.1038/nature24045.

Morikawa Y, Heallen T, Leach J, Xiao Y, and Martin JF. (2017). Dystrophin glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature 547, 227-231 PMCID: PMC5528853; DOI: 10.1038/nature22979.

Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA and Martin JF. (2016). Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature 534, 119-23. PMCID: PMC4999251; DOI: 10.1038/nature17959.

Heallen TR, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, and Martin JF. (2011). Hippo pathway inhibits canonical Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458-461. PMCID: PMC3133743; DOI: 10.1126/science.1199010.